Lyndon A Cornelius: search on Z-Library

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1

Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors

Kyoung Soon Kim, Songfeng Lu, Lyndon A. Cornelius, Louis J. Lombardo, Robert M. Borzilleri, Gretchen M. Schroeder, Christopher Sheng, George Rovnyak, Donald Crews, Robert J. Schmidt, David K. Williams

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 182 KB

english, 2006

2

Discovery of N -(4-(2-Amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a Selective and Orally Efficacious Inhibitor of the Met Kinase Superfamily

Schroeder, Gretchen M., An, Yongmi, Cai, Zhen-Wei, Chen, Xiao-Tao, Clark, Cheryl, Cornelius, Lyndon A. M., Dai, Jun, Gullo-Brown, Johnni, Gupta, Ashok, Henley, Benjamin, Hunt, John T., Jeyaseelan, Rob

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 863 KB

english, 2009

3

Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors

Combs, Donald W., Reese, Kimberly, Cornelius, Lyndon A. M., Gunnet, Joseph W., Cryan, Ellen V., Granger, Kay S., Jordan, Jerold J., Demarest, Keith T.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 648 KB

english, 1995

4

Identification of a potent, selective, and efficacious phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor for the treatment of immunological disorders

Liu, Qingjie, Shi, Qing, Marcoux, David, Batt, Douglas G., Cornelius, Lyndon, Qin, Lan-Ying, Ruan, Zheming, Neels, James, Beaudoin Bertrand, Myra, Srivastava, Anurag S., Li, Ling, Cherney, Robert Jose

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

5

Direct displacement of –OH by nucleophiles in hydroxymethylimidazoles

John E Macor, Lyndon A.M Cornelius, Jacques Y Roberge

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 101 KB

english, 2000

6

Improved P1/P1‘ Substituents for Cyclic Urea Based HIV-1 Protease Inhibitors: Synthesis, Structure−Activity Relationship, and X-ray Crystal Structure Analysis

Nugiel, David A., Jacobs, Kim, Cornelius, Lyndon, Chang, Chong-Hwan, Jadhav, Prabhakar K., Holler, Edward R., Klabe, Ronald M., Bacheler, Lee T., Cordova, Beverly, Garber, Sena, Reid, Carol, Logue, Ke

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 302 KB

english, 1997

7

A Convenient Synthesis of Mono- and Polyhalogenated Benzocyclanones

Cornelius, Lyndon A. M., Combs, Donald W.

Journal:

Synthetic Communications

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

8

Facile Preparation of 2,6-Disubstituted Purines Using Solid-Phase Chemistry

Nugiel, David A., Cornelius, Lyndon A. M., Corbett, Jeffrey W.

Journal:

Journal of Organic Chemistry

Year:

1997

Language:

english

File:

PDF, 175 KB

english, 1997

9

Neutral acylation (protection) of the indole nitrogen: A simple synthesis of indole-1-carboxylates, indole-1-thiocarboxylates and indole-1-carboxamides

John E. Macor, Alison Cuff, Lyndon Cornelius

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 187 KB

english, 1999

10

Discovery of N -Isoxazolyl Biphenylsulfonamides as Potent Dual Angiotensin II and Endothelin A Receptor Antagonists

Murugesan, Natesan, Tellew, John E., Gu, Zhengxiang, Kunst, Bridgette L., Fadnis, Leena, Cornelius, Lyndon A., Baska, Rose Ann F., Yang, Yifan, Beyer, Sophie M., Monshizadegan, Hossain, Dickinson, Ken

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 147 KB

english, 2002

11

Discovery of 4′-[(Imidazol-1-yl)methyl]biphenyl-2-sulfonamides as dual endothelin/Angiotensin II receptor antagonists

John E Tellew, Rose Ann F Baska, Sophie M Beyer, Kenneth E Carlson, Lyndon A Cornelius, Leena Fadnis, Zhengxiang Gu, Bridgette L Kunst, Mark C Kowala, Hossain Monshizadegan, Natesan Murugesan, Carol S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 142 KB

english, 2003

12

Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers

Modugno, Michele, Banfi, Patrizia, Gasparri, Fabio, Borzilleri, Robert, Carter, Percy, Cornelius, Lyndon, Gottardis, Marco, Lee, Ving, Mapelli, Claudio, Naglich, Joseph G., Tebben, Andrew, Vite, Grego

Journal:

Experimental Cell Research

Year:

2015

Language:

english

File:

PDF, 2.21 MB

english, 2015

13

Corrigendum to “Direct displacement of –OH by nucleophiles in hydroxymethylimidazoles”: [Tetrahedron Letters 41 (2000) 2777]

John E Macor, Lyndon A.M Cornelius, Jacques Y Roberge

Journal:

Tetrahedron Letters

Year:

2000

File:

PDF, 87 KB

2000

14

Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene

Cornelius, Lyndon A. M., Bone, Richard G. A., Hastings, Riley H., Deardorff, Matthew A., Scharlach, Randall A., Hauptmann, Brett E., Stankovic, Charles S., Pinnick, Harold W.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 408 KB

english, 1993

15

Synthesis of 2-acetylbicyclo[2.2.1]hept-2-ene. [Erratum to document cited in CA119(3):27738j]

Cornelius, Lyndon A. M., Bone, Richard G. A., Hastings, Riley H., Deardorff, Matthew A., Scharlach, Randall A., Hauptmann, Brett E., Stankovic, Charles J., Pinnick, Harold W.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 78 KB

english, 1993

16

DBS sampling can be used to stabilize prodrugs in drug discovery rodent studies without the addition of esterase inhibitors

D’Arienzo, Celia J, Ji, Qin C, Discenza, Lorell, Cornelius, Georgia, Hynes, John, Cornelius, Lyndon, Santella, Joseph B, Olah, Timothy

Journal:

Year:

2010

Language:

english

File:

PDF, 855 KB

english, 2010

17

Discovery of BMS-986251: A Clinically Viable, Potent, and Selective RORÎ³t Inverse Agonist

Cherney, Robert J., Cornelius, Lyndon A. M., Srivastava, Anurag, Weigelt, Carolyn A., Marcoux, David, Duan, James J.-W., Shi, Qing, Batt, Douglas G., Liu, Qingjie, Yip, Shiuhang, Wu, Dauh-Rurng, Ruzan

Journal:

ACS Medicinal Chemistry Letters

Year:

2020

File:

PDF, 526 KB

2020

18

ChemInform Abstract: Studies Towards Understanding the Mechanism of the Unusual Rearrangement of Certain 5-Propargyloxyindoles.

John E. Macor, Oren D. Langer, Jack Z. Gougoutas, Mary F. Malley, Lyndon A. M. Cornelius

Journal:

Year:

2000

File:

PDF, 30 KB

2000

19

Monochlorination of Electron-Rich Arylalkyl- and Heteroarylalkyl-Amines and Amino Acids Using Sulfuryl Chloride.

Guixue Yu, Helen J. Mason, Kim Galdi, Ximao Wu, Lyndon Cornelius, Ning Zhao, Michael Witkus, William R. Ewing, John E. Macor

Journal:

Year:

2003

File:

PDF, 173 KB

2003

20

Discovery of N -(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Lombardo, Louis J., Lee, Francis Y., Chen, Ping, Norris, Derek, Barrish, Joel C., Behnia, Kamelia, Castaneda, Stephen, Cornelius, Lyndon A. M., Das, Jagabandhu, Doweyko, Arthur M., Fairchild, Craig, H

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 307 KB

english, 2004

21

Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors

Qin, Lan-Ying, Ruan, Zheming, Cherney, Robert J., Dhar, T.G. Murali, Neels, James, Weigelt, Carolyn A., Sack, John S., Srivastava, Anurag S., Cornelius, Lyndon A.M., Tino, Joseph A., Stefanski, Kevin,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 888 KB

english, 2017

22

Discovery of orally active pyrrolopyridine- and aminopyridine-based Met kinase inhibitors

Zhen-Wei Cai, Donna Wei, Gretchen M. Schroeder, Lyndon A.M. Cornelius, Kyoung Kim, Xiao-Tao Chen, Robert J. Schmidt, David K. Williams, John S. Tokarski, Yongmi An, John S. Sack, Veeraswamy Manne, Amr

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 276 KB

english, 2008

23

ChemInform Abstract: Direct Displacement of -OH by Nucleophiles in Hydroxymethylimidazoles.

John E. Macor, Lyndon A. M. Cornelius, Jacques Y. Roberge

Journal:

Year:

2000

File:

PDF, 28 KB

2000

24

Studies towards understanding the mechanism of the unusual rearrangement of certain 5-propargyloxyindoles

John E Macor, Oren D Langer, Jack Z Gougoutas, Mary F Malley, Lyndon A.M Cornelius

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 392 KB

english, 2000

25

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity

Oderinde, Martins S., Mao, Edna, Ramirez, Antonio, Pawluczyk, Joseph, Jorge, Christine, Cornelius, Lyndon A. M., Kempson, James, Vetrichelvan, Muthalagu, Pitchai, Manivel, Gupta, Anuradha, Gupta, Arun

Journal:

Journal of the American Chemical Society

Year:

2020

File:

PDF, 516 KB

2020

26

ChemInform Abstract: Neutral Acylation (Protection) of the Indole Nitrogen: A Simple Synthesis of Indole-1-carboxylates, Indole-1-thiocarboxylates and Indole-1-carboxamides.

John E. Macor, Alison Cuff, Lyndon Cornelius

Journal:

Year:

1999

File:

PDF, 29 KB

1999

27

Mono-Chlorination of Electron-Rich Arylalkyl- and Heteroarylalkyl-amines and Amino Acids Using Sulfuryl Chloride

Yu, Guixue, Mason, Helen J., Galdi, Kim, Wu, Ximao, Cornelius, Lyndon, Zhao, Ning, Witkus, Michael, Ewing, William R., Macor, John E.

Journal:

Year:

2003

Language:

english

File:

PDF, 76 KB

english, 2003

28

Synthesis of 1-(tert-Butyl) 4-Methyl (1R,2S,4R)-2-Methylcyclohexane-1,4-Dicarboxylate from Hagemannâs tert-Butyl Ester for an Improved Synthesis of BMS-986251

Cornelius, Lyndon A. M., Li, Jianqing, Smith, Daniel, Krishnananthan, Subramaniam, Yip, Shiuhang, Wu, Dauh-Rurng, Pawluczyk, Joseph, Aulakh, Darpandeep, Sarjeant, Amy A., Kempson, James, Tino, Joseph

Journal:

Journal of Organic Chemistry

Year:

2020

File:

PDF, 468 KB

2020

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